The combined effect of Algomed and a quadruple herbal brew of Iranian traditional medicine on the severity and outcome of COVID-19; a randomized controlled clinical trial recruiting inpatients

Introduction: Given the importance of coronavirus disease 2019 (COVID-19) as a worldwide issue and its health, psychological social effects some serious complications consequences, it needs to find appropriate treatment for this emerging disease. Objectives: To evaluate effectiveness combination Algomed Mentha longifolia, Matricaria recutita, Althaea rosea Malva sylvestris on severity outcomes COVID-19. Patients Methods: In Randomized clinical trial we included 68 participants with confirmed COVID-19 through PCR tests and/or CT scan, who were admitted non-ICU wards. The intervention group received four 300-mg tablets daily, quadruple herbal brew three times day additionally while control routine treatments. was prepared using large teabag containing 6 g herbs (2 2 M. 1.4 0.6 A. rosea). patients compared daily from their admission end third in terms para-clinical symptoms, outcomes. Results: two groups not significantly different age (P=0.657) gender (P=0.798). median inter-quartile range length stay respectively 3 2-4 days 5 3-9 controls, higher (P<0.001). Comparing difference between first values showed significant white blood cells count, reduction 432.9 vs. an increase 65.5 controls (P=0.049). Except diarrhea, which happened more (P=0.020), other variations. Conclusion: present study results indicated reducing stay. It is suggested that findings research should be by detailed bigger sample size. also recommended same or similar conducted geographic locations world confirm outcome research. main limitation performed only hospitalized had milder form severity. Therefore, benefits interventions cannot generalized all patients. Trial Registration: Registration protocol has been approved Iranian Registry Clinical Trials (#IRCT20151228025732N51, https://en.irct.ir/trial/46828, ethical code#IR.SEMUMS.REC.1398.325).